Pang, Yong Kek and Ismail, Ahmad Izuanuddin and Chan, Yoke Fun and Cheong, Adelina and Chong, Yoong Min and Doshi, Paras and Lau, Joanne Zhi Han and Khor, Jean and Wang, Lilian Phei Lian and Leong, Chee Loon and Musa, Aisya Natasya and Ng, Kee Sing and Poh, Mau Ern and Sam, Jamal I-Ching and Tan, Jiunn Liang and Zim, Mohd Arif Mohd and Taurel, Anne-Frieda (2021) Influenza in Malaysian adult patients hospitalized with community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease or asthma: A multicenter, active surveillance study. BMC Infectious Diseases, 21 (1). ISSN 1471-2334, DOI https://doi.org/10.1186/s12879-021-06360-9.
Full text not available from this repository.Abstract
BackgroundAvailable data on influenza burden across Southeast Asia are largely limited to pediatric populations, with inconsistent findings.MethodsWe conducted a multicenter, hospital-based active surveillance study of adults in Malaysia with community-acquired pneumonia (CAP), acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute exacerbation of asthma (AEBA), who had influenza-like illness <= 10days before hospitalization. We estimated the rate of laboratory-confirmed influenza and associated complications over 13months (July 2018-August 2019) and described the distribution of causative influenza strains. We evaluated predictors of laboratory-confirmed influenza and severe clinical outcomes using multivariate analysis.ResultsOf 1106 included patients, 114 (10.3%) were influenza-positive; most were influenza A (85.1%), with A/H1N1pdm09 being the predominant circulating strain during the study following a shift from A/H3N2 from January-February 2019 onwards. In multivariate analyses, an absence of comorbidities (none versus any comorbidity OR (95%CI), 0.565 (0.329-0.970)], p =0.038) and of dyspnea (0.544 (0.341-0.868)], p =0.011) were associated with increased risk of influenza positivity. Overall, 184/1106 (16.6%) patients were admitted to intensive care or high-dependency units (ICU/HDU) (13.2% were influenza positive) and 26/1106 (2.4%) died (2.6% were influenza positive). Males were more likely to have a severe outcome (ICU/HDU admission or death).ConclusionsInfluenza was a significant contributor to hospitalizations associated with CAP, AECOPD and AEBA. However, it was not associated with ICU/HDU admission in this population.Study registration, NMRR ID: NMRR-17-889-35,174.
| Item Type: | Article |
|---|---|
| Funders: | Sanofi Pasteur |
| Uncontrolled Keywords: | Influenza;Human;Hospitalization;Adults;Epidemiology; Influenza-like illness;Malaysia;Outcomes |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 10 Jun 2022 08:22 |
| Last Modified: | 10 Jun 2022 08:25 |
| URI: | http://eprints.um.edu.my/id/eprint/34647 |
Actions (login required)
 |
View Item |
