Vuong, Nguyen Lam and Lam, Phung Khanh and Ming, Damien Keng Yen and Duyen, Huynh Thi Le and Nguyen, Nguyet Minh and Tam, Dong Thi Hoai and Hue, Kien Duong Thi and Chau, Nguyen V. V. and Chanpheaktra, Ngoun and Lum, Lucy Chai See and Pleites, Ernesto and Simmons, Cameron P. and Rosenberger, Kerstin D. and Jaenisch, Thomas and Bell, David and Acestor, Nathalie and Halleux, Christine and Olliaro, Piero L. and Wills, Bridget A. and Geskus, Ronald B. and Yacoub, Sophie (2021) Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes. eLife, 10. ISSN 2050-084X, DOI https://doi.org/10.7554/eLife.67460.
Full text not available from this repository.Abstract
Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/ moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/ MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.
| Item Type: | Article |
|---|---|
| Funders: | European Commission[FP7-281803 IDAMS], World Health Organization UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Bill and Melinda Gates Foundation The Global Good Fund I, LLC at Intellectual Ventures |
| Uncontrolled Keywords: | This study was supported by the EU's Seventh Framework Programme (FP7-281803; IDAMS);The WHO;And the Bill and Melinda Gates Foundation |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 31 May 2022 08:18 |
| Last Modified: | 31 May 2022 08:18 |
| URI: | http://eprints.um.edu.my/id/eprint/34643 |
Actions (login required)
 |
View Item |
