Ruzaidi, Dania Adila Ahmad and Mahat, Mohd Muzamir and Sofian, Zarif Mohamed and Hashim, Nikman Adli Nor and Osman, Hazwanee and Nawawi, Mohd Azizi and Ramli, Rosmamuhamadani and Jantan, Khairil Anuar and Aizamddin, Muhammad Faiz and Azman, Hazeeq Hazwan and Chang, Yee Hui Robin and Hamzah, Hairul Hisham (2021) Synthesis and characterization of porous, electro-conductive chitosan-gelatin-agar-based PEDOT: PSS scaffolds for potential use in tissue engineering. Polymers, 13 (17). ISSN 2073-4360, DOI https://doi.org/10.3390/polym13172901.
Full text not available from this repository.Abstract
Herein we report the synthesis and characterization of electro-conductive chitosan-gelatin-agar (Cs-Gel-Agar) based PEDOT: PSS hydrogels for tissue engineering. Cs-Gel-Agar porous hydrogels with 0-2.0% (v/v) PEDOT: PSS were fabricated using a thermal reverse casting method where low melting agarose served as the pore template. Sample characterizations were performed by means of scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction analysis (XRD) and electrochemical impedance spectroscopy (EIS). Our results showed enhanced electrical conductivity of the cs-gel-agar hydrogels when mixed with DMSO-doped PEDOT: PSS wherein the optimum mixing ratio was observed at 1% (v/v) with a conductivity value of 3.35 x 10(-4) S cm(-1). However, increasing the PEDOT: PSS content up to 1.5 % (v/v) resulted in reduced conductivity to 3.28 x 10(-4) S cm(-1). We conducted in vitro stability tests on the porous hydrogels using phosphate-buffered saline (PBS) solution and investigated the hydrogels' performances through physical observations and ATR-FTIR characterization. The present study provides promising preliminary data on the potential use of Cs-Gel-Agar-based PEDOT: PSS hydrogel for tissue engineering, and these, hence, warrant further investigation to assess their capability as biocompatible scaffolds.
| Item Type: | Article |
|---|---|
| Funders: | University Teknologi MARA Malaysia[600-RMC/GPK 5/3 (177/2020)] |
| Uncontrolled Keywords: | Chitosan;PEDOT;PSS;Scaffold;Electrical conductivity;Tissue engineering |
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 15 Sep 2022 03:31 |
| Last Modified: | 15 Sep 2022 03:31 |
| URI: | http://eprints.um.edu.my/id/eprint/34559 |
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