Rehman, Inayat Ur and Ahmed, Raheel and Rahman, Aziz Ur and Wu, David Bin Chia and Munib, Syed and Shah, Yasar and Khan, Nisar Ahmad and Rehman, Ateeq Ur and Lee, Learn Han and Chan, Kok Gan and Khan, Tahir Mehmood (2021) Effectiveness and safety profiling of zolpidem and acupressure in CKD associated pruritus An interventional study. Medicine, 100 (21). ISSN 0025-7974, DOI https://doi.org/10.1097/MD.0000000000025995.
Full text not available from this repository.Abstract
Background: Chronic kidney disease (CKD)-associated pruritus (CKD-aP) contributes to poor quality of life, including reduced sleep quality and poor sleep quality is a source of patient stress and is linked to lower health-related quality of life. This study aimed to investigate the effectiveness of zolpidem 10 mg and acupressure therapy on foot acupoints to improve the sleep quality and overall quality of life among hemodialysis patients suffering from CKD-aP. Method: A multicenter, prospective, randomized, parallel-design, open label interventional study to estimate the effectiveness of zolpidem (10 mg) oral tablets versus acupressure on sleep quality and quality of life in patients with CKD-aP on hemodialysis. A total of 58 hemodialysis patients having sleep disturbance due to CKD-aP completed the entire 8-week follow-up. The patients were divided into a control (acupressure) group of 28 patients and an intervention (zolpidem) group of 30 patients. Results: A total of 58 patients having CKD-aP and sleep disturbance were recruited. In the control group there was a reduction in the PSQI score with a mean +/- SD from 12.28 +/- 3.59 to 9.25 +/- 3.99, while in the intervention group the reduction in PSQI score with a mean +/- SD was from 14.73 +/- 4.14 to 10.03 +/- 4.04 from baseline to endpoint. However, the EQ5D index score and EQ-visual analogue scale (VAS) at baseline for the control group with a mean +/- SD was 0.49 +/- 0.30 and 50.17 +/- 8.65, respectively, while for the intervention group the values were 0.62 +/- 0.26 and 47.17 +/- 5.82, respectively. The mean EQ5D index score in the control group improved from 0.49 +/- 0.30 to 0.53 +/- 0.30, but in the intervention group there was no statistical improvement in mean EQ5D index score from 0.62 +/- 0.26 to 0.62 +/- 0.27 from baseline to week 8. The EQ 5D improved in both groups and the EQ-VAS score was 2.67 points higher at week 8 as compared to baseline in the control group, while in the intervention group the score was 3.33 points higher at week 8 as compared to baseline. Comparing with baseline, the PSQI scores were significantly reduced after week 4 and week 8 (P = < .001). Furthermore, at the end of the study, the PSQI scores were significantly higher in the control as compared to the intervention group (P = .012). Conclusion: An improvement in sleep quality and quality of life among CKD-aP patients on hemodialysis has been observed in both the control and intervention groups. Zolpidem and acupressure safety profiling showed no severe adverse effect other that drowsiness, nausea and daytime sleeping already reported in literature of zolpidem.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant (FRGS grant) [Grant No: KGC FP022-2018A] |
| Uncontrolled Keywords: | CKD-associated pruritus; Acupressure; Zolpidem; Hemodialysis; Interventional study; Quality of life; EQ5D-3L; PSQI; Urdu 5D-itch scale |
| Subjects: | Q Science > Q Science (General) R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 31 May 2022 08:10 |
| Last Modified: | 31 May 2022 08:10 |
| URI: | http://eprints.um.edu.my/id/eprint/34463 |
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