Rozenan, Nooraqilah Che and Zamakshshari, Nor Hisam and Leong, Kok Hoong and Mohd Hashim, Najihah and Ahmad, Khadher and Abd Razzak, Munirah and Mohd Yusof, Zulkifli and Awang, Khalijah and Ismail, Abd Aziz and Othman, Rozana (2021) Biological and analytical investigations of alpha-glucosidase inhibitory and anti-oxidant activities on selected Malaysian medicinal plants. Sains Malaysiana, 50 (9). pp. 2625-2640. ISSN 0126-6039, DOI https://doi.org/10.17576/jsm-2021-5009-11.
Full text not available from this repository.Abstract
This study was performed to establish anti-diabetic and anti-oxidant properties, and to carry out phytochemical analysis of selected local plants which are traditionally used as medicinal plants. Local plants involved in this study were Lawsonia inennis, Punica granatum, Dryobalanops aromatica, Ziziphus mauritiana, and Ocimum basilicum. Solvent extraction was performed using maceration method with solvents of increasing polarity. Alpha-glucosidase inhibition assay was performed on all extracts to ascertain their anti-diabetic potentials. The extracts were screened for antioxidant activity using anti-oxidant assays (FRAP, DPPH, TAOC, ABTS, and BCB) and quantitative phytochemical analyses (TPC and TFC). Chemical profiling using LCMS and GCMS was performed on extracts with high biological activities. Methanol extracts of D. aromatica bark and leaves showed the most potent inhibition of alpha-glucosidase with IC50 values of 0.63 +/- 0.03 mu g/mL and 0.98 +/- 0.02 mu g/mL, respectively. Both extracts exhibited similar anti-oxidant activity on all five assays and possessed high phenolic contents with values of 266.79 and 261.69 GAE, respectively. The results obtained suggested that amongst the selected plants studied, D. aromatica showed high anti-oxidant activity and anti-diabetic activity (via inhibition of alpha-glucosidase). This is the first report that highlights the anti-diabetic potential of D. aromatica.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education through the Trans Disciplinary Research Grant Scheme [TR001C-2014A], USIM C grant [PPP/UCG-0116/FPQS/30/14316] |
| Uncontrolled Keywords: | Alpha-glucosidase; Anti-diabetic; Anti-oxidant; Dryobalanops aromatica; Medicinal plants |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Academy of Islamic Studies > Dept of Al-Quran & Al- Hadith Faculty of Science > Department of Chemistry Faculty of Pharmacy > Department of Pharmaceutical Chemistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 09 Jun 2022 04:14 |
| Last Modified: | 09 Jun 2022 04:14 |
| URI: | http://eprints.um.edu.my/id/eprint/34382 |
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