Ledowski, Thomas and Szabo-Maak, Zoltan and San Loh, Pui and Turlach, Berwin A. and Yang, Hong Seuk and de Boer, Hans D. and Asztalos, Laszlo and Shariffuddin, Ina Ismiarti and Chan, Lucy and Fulesdi, Bela (2021) Reversal of residual neuromuscular block with neostigmine or sugammadex and postoperative pulmonary complications: A prospective, randomised, double-blind trial in high-risk older patients. British Journal of Anaesthesia, 127 (2). pp. 316-323. ISSN 0007-0912, DOI https://doi.org/10.1016/j.bja.2021.04.026.
Full text not available from this repository.Abstract
Residual neuromuscular block is associated with an increased risk of postoperative pulmonary complications in retrospective studies. The aim of our study was to investigate prospectively the incidence of postoperative pulmonary complications after reversal with either sugammadex (SUG) or neostigmine (NEO) in high-risk older patients. Methods: We randomly allocated 180 older patients with significant morbidity (ASA physical status 3) >= 75 yr old to reversal of rocuronium with either SUG or NEO. Adverse events in the recovery room and pulmonary complications (defined by a 5-point 0-4; 0= best to 4= worst] outcome score) on postoperative Days 1, 3, and 7 were compared between groups. Results: Data from 168 patients aged 80 (4) yr were analysed; SUG vs NEO resulted in a reduced probability (0.052 vs 0.122) of increased pulmonary outcome score (impaired outcome) on postoperative Day 7, but not on Days 1 and 3. More patients in the NEO group were diagnosed with radiographically confirmed pneumonia (9.6% vs 2.4%; P=0.046). The NEO group showed a non-significant trend towards longer hospital length of stay across all individual centres (combined 9 vs 7.5 days), with a significant difference in Malaysia (6 vs 4 days; P=0.011). Conclusions: Reversal of rocuronium neuromuscular block with SUG resulted in a small, but possibly clinically relevant improvement in pulmonary outcome in a select cohort of high-risk older patients.
| Item Type: | Article |
|---|---|
| Funders: | University of Western Australia |
| Uncontrolled Keywords: | Neostigmine;Neuromuscular block;Perioperative complications; Postoperative pulmonary complications;Reversal;Sugammadex |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 12 Sep 2022 07:56 |
| Last Modified: | 12 Sep 2022 07:56 |
| URI: | http://eprints.um.edu.my/id/eprint/34363 |
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