Cheah, Peng Loon and Krisnan, Thiagu and Wong, Jeannie Hsiu Ding and Rozalli, Faizatul Izza and Fadzli, Farhana and Rahmat, Kartini and Shahrizaila, Nortina and Tan, Li Kuo and Nawawi, Ouzreiah and Ramli, Norlisah (2021) Microstructural integrity of peripheral nerves inCharcot-Marie-Tooth disease: An MRI evaluation study. Journal of Magnetic Resonance Imaging, 53 (2). pp. 437-444. ISSN 1053-1807, DOI https://doi.org/10.1002/jmri.27354.
Full text not available from this repository.Abstract
Charcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited. Purpose To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS). Study Type Prospective case-control. Subjects Nine CMT patients and nine age-matched controls. Field Strength/Sequence 3 T T-1-weighted in-/out-of phase spoiled gradient recalled echo (SPGR) and DTI sequences. Assessment Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in-/out-of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed. Statistical Tests The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done. Results There was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative;P < 0.05) and RD (positive;P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r= -0.795;P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8-100%) and specificity (88.9-100%). Data Conclusion There were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Charcot-Marie-Tooth disease;Sciatic nerve;Peroneal nerve; Diffusion tensor imaging;Peripheral nervous system diseases |
| Subjects: | R Medicine R Medicine > R Medicine (General) > Medical technology R Medicine > RK Dentistry |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 12 Sep 2022 06:32 |
| Last Modified: | 12 Sep 2022 06:32 |
| URI: | http://eprints.um.edu.my/id/eprint/34332 |
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