Cyclic Polyketides with alpha-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study

Azmi, Mohamad Nurul and Saad, Nur Amirah and Abu Bakar, Mohamad Hafizi and Omar, Mohammad Tasyriq Che and Aziz, Ahmad Nazif and Wahab, Habibah A. and Siddiq, Sadia and Choudhary, M. Iqbal and Litaudon, Marc and Awang, Khalijah (2021) Cyclic Polyketides with alpha-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study. Records of Natural Products, 15 (5). pp. 414-419. ISSN 1307-6167, DOI https://doi.org/10.25135/rnp.227.20.11.1889.

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Abstract

A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A ( 1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro alpha-glucosidase inhibition activity. Among them, compounds 3-4 showed potent alpha-glucosidase inhibition activity with IC50 value at 11.9 +/- 2.0 mu M and 19.7 +/- 1.5 mu M, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro alpha-glucosidase enzyme inhibition activity results.

Item Type: Article
Funders: Universiti Sains Malaysia Research Grant RUI [1001.PKIMIA.8012310], Ministry of Higher Education FRGS [FRGS/1/2019/STG01/UMT/03/2]
Uncontrolled Keywords: Endiandra kingiana; Cyclic polyketides; Endiandric acids; Kingianins; Alpha-glucosidase inhibition; Molecular docking
Subjects: Q Science > QD Chemistry
Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms Zaharah Ramly
Date Deposited: 13 Jun 2022 01:38
Last Modified: 13 Jun 2022 01:38
URI: http://eprints.um.edu.my/id/eprint/34323

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