Pang, W.W. and Abdul-Rahman, P.S. and Wan-Ibrahim, W.I. and Hashim, Onn Haji (2010) Can the acute-phase reactant proteins be used as cancer biomarkers? International Journal of Biological Markers, 25 (1). pp. 1-11. ISSN 0393-6155,
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Abstract
The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers. (Int J Biol Markers 2010: 25: 1-11)
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur - Malaysia |
| Uncontrolled Keywords: | Acute-phase reactant proteins, Biomarker, Cancer, Diagnosis, Serum |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 09 Jul 2012 08:52 |
| Last Modified: | 24 Oct 2019 08:24 |
| URI: | http://eprints.um.edu.my/id/eprint/3432 |
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