Khalid, Awais and Ahmad, Pervaiz and Alharthi, Abdulrahman I. and Muhammad, Saleh and Khandaker, Mayeen Uddin and Faruque, Mohammad Rashed Iqbal and Din, Israf Ud and Alotaibi, Mshari A. and Khan, Abdulhameed (2021) Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains. PLoS ONE, 16 (5). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0251082.
Full text not available from this repository.Abstract
A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H(2)O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains.
| Item Type: | Article |
|---|---|
| Funders: | Research Universiti Grant, Universiti Kebangsaan Malaysia, Geran Universiti Penyelidikan (GUP) (2018-134) |
| Uncontrolled Keywords: | Synergistic effects; Cu-doped ZnO nanoantibiotic; Gram-positive bacterial strains |
| Subjects: | Q Science > Q Science (General) Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Physics |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 07 Sep 2022 07:28 |
| Last Modified: | 07 Sep 2022 07:28 |
| URI: | http://eprints.um.edu.my/id/eprint/34197 |
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