Low, Chuen Xian and Tan, Loh Teng-Hern and Ab Mutalib, Nurul-Syakima and Pusparajah, Priyia and Goh, Bey-Hing and Chan, Kok-Gan and Letchumanan, Vengadesh and Lee, Learn-Han (2021) Unveiling the impact of antibiotics and alternative methods for animal husbandry: A review. Antibiotics-Basel, 10 (5). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics10050578.
Full text not available from this repository.Abstract
Since the 1950s, antibiotics have been used in the field of animal husbandry for growth promotion, therapy and disease prophylaxis. It is estimated that up to 80% of the antibiotics produced by the pharmaceutical industries are used in food production. Most of the antibiotics are used as feed additives at sub-therapeutic levels to promote growth. However, studies show the indiscriminate use of antibiotics has led to the emergence of multidrug-resistant pathogens that threaten both animal health and human health, including vancomycin-resistant Enterococcus (VRE), Methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE). This scenario is further complicated by the slow progress in achieving scientific breakthroughs in uncovering novel antibiotics following the 1960s. Most of the pharmaceutical industries have long diverted research funds away from the field of antibiotic discovery to more lucrative areas of drug development. If this situation is allowed to continue, humans will return to the pre-antibiotics era and potentially succumb to huge health and economic consequences. Fortunately, studies investigating various alternatives to antibiotics use in livestock show promising results. These alternatives include the application of bacteriophages and phage derived peptidoglycan degrading enzymes, engineered peptides, egg yolk antibodies, probiotics, prebiotics and synbiotics, as well as quorum quenching molecules. Therefore, this review aims to discuss the use of growth-promoting antibiotics and their impact on livestock and provide insights on the alternative approaches for animal husbandry.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant (FRGS) [FP022-2018A], Fundamental Research Grant Scheme [FRGS/1/2019/SKK08/MUSM/02/7], Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences [MBRS/JCSMHS/02/2020] |
| Uncontrolled Keywords: | Antibiotic; Multidrug-resistant; Growth-promoting; Livestock; Husbandry |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Aug 2022 01:23 |
| Last Modified: | 01 Aug 2022 01:23 |
| URI: | http://eprints.um.edu.my/id/eprint/34107 |
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