Thiang, Ee Lean and Lee, Choon Weng and Takada, Hideshige and Seki, Kanako and Takei, Ayaka and Suzuki, Satoru and Wang, Aijun and Bong, Chui Wei (2021) Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia. Ecosystem Health and Sustainability, 7 (1). ISSN 2096-4129, DOI https://doi.org/10.1080/20964129.2021.1926337.
Full text not available from this repository.Abstract
Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR respectively. Risk quotients in European technical guidance document on risk assessment was used to assess the potential environmental risk. Results: We detected 23 antibiotics with tetracyclines, sulfonamides and quinolones were the most frequently detected classes, indicating a wide distribution of antibiotics in Malaysian aquaculture farms. The dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture farms. The ARGs (10(-3) copies/16S) were detected in >90% of the sites except for sul3. Ciprofloxacin, enrofloxacin, norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan, Perak and Pahang. Conclusion: Relative to Asian aquaculture farms, the residues detected here were at low or moderate levels except for quinolones. This study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [25257402], Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [16H01782] [17H04476] |
| Uncontrolled Keywords: | Antibiotic residues; Resistance genes; Risk assessment; Aquaculture |
| Subjects: | G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences Institute of Advanced Studies Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 08 Jul 2022 00:58 |
| Last Modified: | 08 Jul 2022 00:58 |
| URI: | http://eprints.um.edu.my/id/eprint/33964 |
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