Yoon, Sook-Yee and Wong, Siu Wan and Lim, Joanna and Ahmad, Syuhada and Mariapun, Shivaani and Padmanabhan, Heamanthaa and Hassan, Nur Tiara and Lau, Shao Yan and Ch'ng, Gaik-Siew and Haniffa, Muzhirah and Ong, Winnie P. and Rethanavelu, Kavitha and Moey, Lip Hen and Keng, Wee Teik and Omar, Jamil and Mohd Abas, Mohd Norazam and Yong, Chee Meng and Ramasamy, Vickneswaren and Md Noor, Mohd Rushdan and Aliyas, Ismail and Lim, Michael C. K. and Suberamaniam, Anuradha and Mat Adenan, Noor Azmi and Ahmad, Zatul Akmar and Ho, Gwo Fuang and Abdul Malik, Rozita and Subramaniam, Suguna and Khoo, Boom Ping and Raja, Arivendran and Chin, Yeung Sing and Sim, Wee Wee and Teh, Beng Hock and Kho, Swee Kiong and Ong, Eunice S. E. and Voon, Pei Jye and Ismail, Ghazali and Lee, Chui Ling and Abdullah, Badrul Zaman and Loo, Kwong Sheng and Lim, Chun Sen and Lee, Saw Joo and Lim, Keng Joo Lim and Shafiee, Mohamad Nasir and Ismail, Fuad and Latiff, Zarina Abdul and Ismail, Mohd Pazudin and Mohamed Jamli, Mohamad Faiz and Kumarasamy, Suresh and Leong, Kin Wah and Low, John and Md Yusof, Mastura and Ahmad Mustafa, Ahmad Muzamir and Mat Ali, Nor Huda and Makanjang, Mary and Tayib, Shahila and Cheah, Nellie and Lim, Boon Kiong and Fong, Chee Kin and Foo, Yoke Ching and Mellor Abdullah, Matin and Tan, Teck Sin and Chow, Doris S. Y. and Ho, Kean Fatt and Raman, Rakesh and Radzi, Ahmad and Deniel, Azura and Teoh, Daren C. Y. and Ang, Soo Fan and Joseph, Joseph K. and Ng, Paul Hock Oon and Tho, Lye-Mun and Ahmad, Azura Rozila and Muin, Ileena and Bleiker, Eveline and George, Angela and Thong, Meow-Keong and Woo, Yin Ling and Teo, Soo Hwang (2022) Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes. Journal of Medical Genetics, 59 (3). pp. 220-229. ISSN 0022-2593, DOI https://doi.org/10.1136/jmedgenet-2020-107416.
Full text not available from this repository.Abstract
Background Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming. Methods The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer. Results Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms. Conclusion The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.
| Item Type: | Article |
|---|---|
| Funders: | Yayasan Sime Darby, AstraZeneca External Investigator Grant, Yayasan PETRONAS, Khind Starfish Foundation |
| Uncontrolled Keywords: | Genetic counseling; Genetic testing; Gynecology; Health services research; Medical oncology |
| Subjects: | R Medicine > R Medicine (General) > Medical technology R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Obstetrics & Gynaecology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Apr 2022 04:47 |
| Last Modified: | 23 Apr 2022 04:47 |
| URI: | http://eprints.um.edu.my/id/eprint/33851 |
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