Phenotypic profile of Aedes albopictus (Skuse) exposed to pyrethroid-based mat vaporizers and underlying detoxification mechanisms: A statewide report in Selangor, Malaysia

Azratul-Hizayu, Taib and Chen, Chee Dhang and Lau, Koon Weng and Azrizal-Wahid, Noor and Tan, Tiong Kai and Lim, Yvonne Ai Lian and Sofian-Azirun, Mohd and Low, Van Lun (2022) Phenotypic profile of Aedes albopictus (Skuse) exposed to pyrethroid-based mat vaporizers and underlying detoxification mechanisms: A statewide report in Selangor, Malaysia. Parasitology International, 86. ISSN 1383-5769, DOI https://doi.org/10.1016/j.parint.2021.102483.

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Abstract

This study examines the biological efficacy of four mosquito mat vaporizers each containing different active ingredients: prallethrin with PBO, dimefluthrin, prallethrin, and d-allethrin. The glass chamber assay was used to evaluate their efficacy on Aedes albopictus (Skuse) (Diptera: Culicidae) from nine districts in Selangor, Malaysia. Aedes albopictus exhibited different knockdown rates, with 50% knockdown times, KT50, varying from 1.19 to 2.00 min, 1.22 to 2.20 min, 1.39 to 5.85 min, and 1.39 to 1.92 min for prallethrin with PBO, dimefluthrin, prallethrin and d-allethrin, respectively. In general, all populations of Ae. albopictus were completely knocked down after exposure to all active ingredients except Hulu Selangor population, which showed 96.00% knockdown against d-allethrin. On the contrary, mortality rates were observed from 84.00-100.00%, 84.00-100.00%, 90.67-100.00% and 90.67-100.00% in populations tested with prallethrin with PBO, dimefluthrin, prallethrin and d-allethrin, respectively. Moreover, significant correlations between mortality rates of prallethrin with PBO vs dimefluthrin (r = 0.836, P = 0.003), prallethrin with PBO vs prallethrin (r = 0.760, P = 0.011), and prallethrin vs d-allethrin (r = 0.694, P = 0.026) were also observed, suggesting cross-resistance among pyrethmids. d-allethrin was found to be high in insecticidal activity, followed by prallethrin, prallethrin with PBO, and dimefluthrin. In consistent with mortality due to insecticide exposure, elevated levels of enzyme activities were also demonstrated in Sabak Bernam, Hulu Selangor, Gombak, Petaling, Hulu Langat and Klang populations.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Insecticide resistance;Prallethrin;Dimefluthrin;d-allethrin; Enzyme assays;Malaysia
Subjects: R Medicine
R Medicine > R Medicine (General)
R Medicine > RB Pathology
R Medicine > RB Pathology > Theories of disease. Etiology. Pathogenesis
Divisions: Faculty of Science
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Jul 2022 02:47
Last Modified: 25 Jul 2022 02:47
URI: http://eprints.um.edu.my/id/eprint/33720

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