Sirkkunan, Devindraan and Pingguan-Murphy, Belinda and Muhamad, Farina (2022) Directing axonal growth: A review on the fabrication of fibrous scaffolds that promotes the orientation of axons. Gels, 8 (1). ISSN 2310-2861, DOI https://doi.org/10.3390/gels8010025.
Full text not available from this repository.Abstract
Tissues are commonly defined as groups of cells that have similar structure and uniformly perform a specialized function. A lesser-known fact is that the placement of these cells within these tissues plays an important role in executing its functions, especially for neuronal cells. Hence, the design of a functional neural scaffold has to mirror these cell organizations, which are brought about by the configuration of natural extracellular matrix (ECM) structural proteins. In this review, we will briefly discuss the various characteristics considered when making neural scaffolds. We will then focus on the cellular orientation and axonal alignment of neural cells within their ECM and elaborate on the mechanisms involved in this process. A better understanding of these mechanisms could shed more light onto the rationale of fabricating the scaffolds for this specific functionality. Finally, we will discuss the scaffolds used in neural tissue engineering (NTE) and the methods used to fabricate these well-defined constructs.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia[FP096-2018A], Research University Faculty Grant[GPF052A/2020], Research University Faculty Grant[FP096-2018A (FRGS/1/2018/TK05/UM/02/14)] |
| Uncontrolled Keywords: | Cellular orientation;Fiber alignment;Neural tissue engineering |
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Jul 2022 06:25 |
| Last Modified: | 29 Jul 2022 06:25 |
| URI: | http://eprints.um.edu.my/id/eprint/33601 |
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