Thi, Bang Le and Long, Bui Duc and Trung, Trinh Van and Thanh, Nguyen T Van and Ramesh, S. (2022) Nanocrystalline hydroxyapatite prepared at different precursor concentrations: thermal stability, morphology and in vitro cellular response. Ceramics-Silik�ty, 66 (1). pp. 19-27. ISSN 0862-5468, DOI https://doi.org/10.13168/cs.2021.0048.
Full text not available from this repository.Abstract
Hydroxyapatite is widely used for the reconstruction of defective bones due to its similarity with the composition of bone mineral. In this research, nanocrystalline hydroxyapatite (HA) was synthesised using calcium hydroxide and phosphoric acid as starting precursors. Different concentrations of the reactants, viz. 0.5, 1.0, 1.5 and 2.0 mol center dot L-1, were considered to investigate their effect on the thermal stability and morphology of the synthesised HA. The results showed that the synthesised HA exhibited rod-like shaped particles having sizes in the range of 73.4 to 114.5 nm in length and 14.9 to 20.7 nm in width. The HA produced at the reactant concentration of 0.5 and 1.0 mol center dot L-1 was thermally stable up to 1200 degrees C and did not exhibit any secondary phase. However, the HA prepared at the 1.5 mol center dot L-1 concentration decomposed into tricalcium phosphate at 1000 degrees C while the HA prepared at 2.0 mol center dot L-1 decomposed at 1200 degrees C. It was also found that the size of the particles increased with increasing reactant concentrations. The HA produced from the reactant concentration of 1.0 mol center dot L-1 was found to be optimum in terms of the powder characteristics and the in vitro cell studies indicated that osteoblast cells proliferated well on the synthesised HA, thus confirming the biocompatible nature of the produced bioceramic.
| Item Type: | Article |
|---|---|
| Funders: | National Foundation for Science & Technology Development (NAFOSTED) [104.03-2020.36] |
| Uncontrolled Keywords: | Hydroxyapatite; Concentration; Bioceramics; Precipitation |
| Subjects: | T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Faculty of Engineering > Department of Mechanical Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Jul 2022 05:50 |
| Last Modified: | 22 Jul 2022 05:50 |
| URI: | http://eprints.um.edu.my/id/eprint/33523 |
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