Teo, Yin Yin and Misran, Misni (2022) A study of interaction between alpha-tocopherol acetate and fatty acids mixed with polyethoxylated phospholipid in langmuir monolayer at air-aqueous interface. Brazilian Journal of Physics, 52 (1). ISSN 0103-9733, DOI https://doi.org/10.1007/s13538-021-01020-4.
Full text not available from this repository.Abstract
alpha-Tocopherol acetate is a specific type of vitamin E and categorized as a water-insoluble substance and widely used as an antioxidant. Molecular interactions among fatty acid/polyethoxylated phospholipid with alpha-tocopherol acetate is of the interest in this study. The effect of the amount alpha-tocopherol acetate on the thermodynamic properties of mixed monolayer fatty acid/polyethoxylated phospholipid monolayers is revealed from the surface pressure - area (pi - A) isotherm. The relevant thermodynamic parameters such as miscibility, surface excess area, compression modulus, and stability of the mixed monolayer on phosphate buffer subphase can be analyzed quantitatively from this study. We found that the mixed monolayer either binary or ternary mixture consisting fatty acid with and without the presence of polyethoxylated phospholipid is miscible with alpha-tocopherol acetate. The compatibility of alpha-tocopherol acetate with fatty acid and the mixture of fatty acid/polyethoxylated phospholipid monolayer relied on acyl chain length and degree of unsaturation of fatty acid. Moreover, molecular weight of polyethoxylated phospholipid also plays a significant role in determination of monolayer stability. The most favorable combination of each mixture is determined. These findings provide valuable information for formulation and encapsulation of alpha-tocopherol acetate in fatty acid vesicles in addition to promote the understanding of interaction between fatty acid, polyethoxylated phospholipid, and alpha-tocopherol acetate.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya, Malaysia by RU Grant [GPF051B-2018] |
| Uncontrolled Keywords: | Unsaturated fatty acid; Polyethoxylated phospholipid; Monolayer; Surface pressure; Alpha-Tocopherol acetate |
| Subjects: | Q Science > QC Physics |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Aug 2022 00:28 |
| Last Modified: | 15 Aug 2022 00:28 |
| URI: | http://eprints.um.edu.my/id/eprint/33443 |
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