Shah, Syed Tawab and Chowdhury, Zaira Zaman and Johan, Mohd Rafie and Badruddin, Irfan Anjum and Khaleed, H. M. T. and Kamangar, Sarfaraz and Alrobei, Hussein (2022) Surface functionalization of magnetite nanoparticles with multipotent antioxidant as potential magnetic nanoantioxidants and antimicrobial agents. Molecules, 27 (3). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules27030789.
Full text not available from this repository.Abstract
Functionalized magnetite nanoparticles (Fe3O4) were prepared using the coprecipitation method followed by functionalization with a multipotent antioxidant (MPAO). The MPAO was synthesized and analyzed using FTIR and NMR techniques. In this study, the functionalized nanoparticles (IONP@AO) were produced and evaluated using the FTIR, XRD, Raman, HRTEM, FESEM, VSM, and EDX techniques. The average determined particle size of IONP@AO was 10 nanometers. In addition, it demonstrated superparamagnetic properties. The magnitude of saturation magnetization value attained was 45 emu g(-1). Virtual screenings of the MPAO's potential bioactivities and safety profile were performed using PASS analysis and ADMET studies before the synthesis step. For the DPPH test, IONP@AO was found to have a four-fold greater ability to scavenge free radicals than unfunctional IONP. The antimicrobial properties of IONP@AO were also demonstrated against a variety of bacteria and fungi. The interaction of developed nanoantioxiants with biomolecules makes it a broad-spectrum candidate in biomedicine and nanomedicine.
| Item Type: | Article |
|---|---|
| Funders: | King Khalid University [R.G.P 2/74/41] [ST 028-2019] [ICF 073-2019], Universiti Malaya |
| Uncontrolled Keywords: | Functionalization; Magnetite nanoparticles; Nanoantioxiants |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Aug 2022 00:21 |
| Last Modified: | 01 Dec 2023 07:13 |
| URI: | http://eprints.um.edu.my/id/eprint/33435 |
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