Hashemi, Seyyed Alireza and Mousavi, Seyyed Mojtaba and Bahrani, Sonia and Gholami, Ahmad and Chiang, Wei-Hung and Yousefi, Khadije and Omidifar, Navid and Rao, Neralla Vijayakameswara and Ramakrishna, Seeram and Babapoor, Aziz and Lai, Chin Wei (2022) Bio-enhanced polyrhodanine/graphene Oxide/Fe3O4 nanocomposite with kombucha solvent supernatant as ultra-sensitive biosensor for detection of doxorubicin hydrochloride in biological fluids. Materials Chemistry and Physics, 279. ISSN 0254-0584, DOI https://doi.org/10.1016/j.matchemphys.2022.125743.
Full text not available from this repository.Abstract
Cardiotoxicity and other side effects of current antineoplastic agents with narrow therapeutic windows, such as doxorubicin hydrochloride (DOX), have increased the need for advanced real-time monitoring approaches to control their dosage and minimize common side effects. In this study, we reinforced the biocompatible and electrosensitive polymeric structure of polyrhodanine with iron(II,III) oxide (Fe3O4) and coated graphene oxide (GO) with Fe3O4 (GO-Fe3O4) nanoparticles. The resulting hybrid polymeric platform was bio-enhanced by extraction of kombucha solvent supernatant and used as a highly sensitive biosensor with enhanced electroactive C=N+ functional groups for real-time detection of DOX in the human blood plasma sample. The developed platform was well characterized by performing different analyses, and its applicability was evaluated using an electrochemical approach. The results showed the superior sensitivity (167.62 mu A mu M-1 cm(-2)), low detection limit (DL, 0.008 mu M), and quantification limit (QL, 0.056 mu M) of the proposed biosensor. The biosensor detected DOX in the biological fluid with optimal accuracy (>99%), highlighting the ideal performance of the fabricated polymeric biosensor.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Polyrhodanine; Graphene oxide; Kombucha solvent supernatant; Biosensor; Doxorubicin |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Aug 2022 07:39 |
| Last Modified: | 12 Aug 2022 07:39 |
| URI: | http://eprints.um.edu.my/id/eprint/32762 |
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