Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review

Sangeetha, N. and Noorzurani, R. and Kamarul, Tunku (2011) Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review. European Journal of Orthopaedic Surgery & Traumatology, 22 (2). pp. 89-96. ISSN 1633-8065, DOI https://doi.org/10.1007/s00590-011-0798-6.

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Abstract

Purpose The purpose of this systematic review was to analyze and determine the effectiveness of autologous chondrocyte implantation (ACI) when compared with other treatment modalities, which includes microfracture, mosaicplasty, abrasionplasty, bone marrow�derived mesenchymal stem cell (BMSC), and matrix-assisted autologous chondrocyte implantation (MACI). Methods Literature search using online databases PubMed, Scopus, National Institute for Clinical Excellence and Cochrane controlled trial register regarding all cell-based therapies and other interventions for chondral lesions was explored. Data on clinical outcome and repair quality were analyzed. Duplicates and irrelevant articles were omitted. Result Seventeen ( n = 17) studies were included in this review. Among the four trials on ACI versus mosaicplasty, two studies showed no differences in clinical scores, one suggested similar performance while the other suggested better results in tissue quality for ACI. A systematically performed assessment comparing ACI with microfracture shows better clinical outcomes and higher tissue quality after ACI. Studies comparing ACI with MACI or BMSC demonstrated similar results. Although many of these studies had substantial flaws, on the overall, the evidence comparing ACI with other treatment modalities shows better clinical outcomes and higher tissue quality. Conclusion Despite significant differences between the methodologies employed by different researchers, we can conclude that all except two studies demonstrated ACI being the better treatment for cartilage defects. However, final conclusions regarding long-term effects are still difficult, and therefore, future studies are needed to answer the long-term effects of ACI.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, LembahPantai, 50603 Kuala Lumpur, Malaysia e-mail: sangeevv@gmail.com
Uncontrolled Keywords:	Autologous chondrocyte implantation; Articular cartilage; Cartilage repair;Review; Systemic
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	04 Jun 2012 04:33
Last Modified:	10 Oct 2018 08:42
URI:	http://eprints.um.edu.my/id/eprint/3200

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