Arshad, Maria and Hamid, Nazefah Abdul and Chan, Mun Chiang and Ismail, Fuad and Tan, Geok Chin and Pezzella, Francesco and Tan, Ka-Liong (2021) NUB1 and FAT10 proteins as potential novel biomarkers in cancer: A translational perspective. Cells, 10 (9). ISSN 2073-4409, DOI https://doi.org/10.3390/cells10092176.
Full text not available from this repository.Abstract
Cancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa beta, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial-mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme[USIM/FRGS/FPSK/055002/50119] |
| Uncontrolled Keywords: | Biomarker;Cancer;FAT10;NUB1;NUB1L |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RD Surgery |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 22 Aug 2022 04:10 |
| Last Modified: | 22 Aug 2022 04:53 |
| URI: | http://eprints.um.edu.my/id/eprint/28694 |
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