Phan, Chin Lee and Tan, Siew Ngoh and Tan, Sen Mui and Abd Kadir, Sharifah Shahnaz Syed and Ramli, Nur Liyana Mohd and Lim, Teck Onn and Ng, Ching Ching (2021) A variant e13a3 BCR-ABL1 fusion transcript in refractory adult B-cell acute lymphoblastic leukemia achieving complete remission with CAR-Tcell therapy. Cancer Genetics, 250. pp. 20-24. ISSN 2210-7762, DOI https://doi.org/10.1016/j.cancergen.2020.11.003.
Full text not available from this repository.Abstract
Acute lymphoblastic leukemia (ALL) cases with e13a3 fusion transcripts are extremely rare. We report a 24-year-old male with Ph-positive (Ph+) ALL with an aberrant e13a3 fusion transcript treated with CD19-specific chimeric antigen receptor T-cell (CAR-T) therapy. He developed refractory disease postchemotherapy induction, andreceived allogeneic hematopoietic stem cell transplantation (allo-HSCT) after salvage with imatinib in combination with chemotherapy regimen. Unfortunately, the patient relapsed after +90 days post-transplant. He was consented to CAR-T therapy trial and achieved complete remission, highlighting the efficacy of CAR-T treatment in relapsed-refractory B-ALL irrespective of the underlying genetic drivers in leukemia cells . (C) 2020 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Philadelphia-positive; ALL; e13a3; CART therapy; Relapsed/refractory |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Aug 2022 07:43 |
| Last Modified: | 17 Aug 2022 07:43 |
| URI: | http://eprints.um.edu.my/id/eprint/28651 |
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