Izadiyan, Zahra and Shameli, Kamyar and Teow, Sin-Yeang and Yusefi, Mostafa and Kia, Pooneh and Rasouli, Elisa and Tareq, Mohammad Ali (2021) Anticancer activity of 5-Fluorouracil-Loaded Nanoemulsions containing Fe3O4/Au core-shell nanoparticles. Journal of Molecular Structure, 1245. ISSN 0022-2860, DOI https://doi.org/10.1016/j.molstruc.2021.131075.
Full text not available from this repository.Abstract
Nanoemulsions (NEs) as multi-compartmentalized systems are extensively considered as versatile drug delivery systems, due to their multifunctional and tuneable physicochemical properties. Here, water-in oil-in-water (WOW) NEs were formulated using Juglans regia-based Fe3O4/Au-core-shell nanoparticles to encapsulate 5-Fluorouracil (5-FU) for potential colorectal cancer treatment. Response surface methodology, FTIR, TGA, TEM, DLS, VSM, UV-vis spectroscopy, and viscosity measurements were used to characterize the fabricated samples. The analysis confirmed the successful synthesis of Au, Fe3O4, and Fe3O4/Au core-shell nanoparticles with the Juglans regia (J. regia) extract as a green stabilizer and also reducing agent. The NE displayed a spherical-shape and TEM size of similar to 30 nm. It also exhibited good colloidal stability and multifunctional features related to its components. TGA data indicated that 5-FU increased thermal stability after its loading into the nanoemulsion as a drug carrier. 5-FU release from the NE carrier presented a time-delayed behavior and higher release dosage in media at pH 4 compared to pH 7 within 48 h. When tested against colorectal-derived cell lines, 0.78 mu g/mL of 5-FU-loaded Fe3O4/Au core shell NEs showed potent anticancer activity against HCT116 cancerous cells, while exhibiting low toxicity towards CCD112 normal cells. In conclusion, the synthesized 5-FU-loaded NEs can be potently used as an anticancer drug carrier model, owing to its nano-scale size and other functionalities, which should be further studied. (C) 2021 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Takasago Thermal Engineering Co. Ltd. from the research management center (RMC) of Universiti Teknologi Malaysia (UTM) (130000.7343.4B422), Malaysia Japan International Institute of Technology (MJIIT) |
| Uncontrolled Keywords: | Nanoemulsion; 5-Fluorouracil; Fe3O4/Au nanoparticles; Core-shell; Colorectal cancer; Juglans regia |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 03 Mar 2022 02:39 |
| Last Modified: | 03 Mar 2022 02:39 |
| URI: | http://eprints.um.edu.my/id/eprint/28559 |
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