Le, Bang Thi and Ramesh, S. and Long, Bui Duc and Son, Nguyen Anh and Munar, Melvin and Shi, Xingling (2021) Effect of MgO addition on the sinterability, mechanical properties and biological cell activities of sintered silicon-substituted hydroxyapatite. Journal of the Australian Ceramic Society, 57 (3). pp. 857-868. ISSN 2510-1560, DOI https://doi.org/10.1007/s41779-021-00582-5.
Full text not available from this repository.Abstract
The effect of 1 wt% magnesium oxide (MgO) as sintering additive on the sintering behaviour, microstructure, mechanical properties and cell activities of 0.4 and 1.6 wt% silicon-substituted hydroxyapatite (MgO-0.4Si-HA and MgO-1.6Si-HA) was investigated. The powders were synthesized by the wet-chemical neutralization method and the compacts were pressureless sintered in air between 1150 and 1250 degrees C for 2 h. The results showed that MgO-0.4Si-HA promoted the formation of the secondary phase of beta-TCP when sintered at 1250 degrees C, whilst the stability of the hydroxyapatite phase was not disrupted for the MgO-1.6Si-HA. The presence of MgO was found to be beneficial in suppressing grain growth of Si-HA when sintered at 1250 degrees C; however, it did not promote densification at lower temperatures (1150 and 1200 degrees C). It was observed that despite the lower densification, Vickers hardness and compressive strength of the MgO-Si-HA were higher than those of the undoped Si-HA samples. The beneficial effect of MgO in enhancing the biocompatibility of Si-HA has been revealed. It was found that the MgO-doped samples dramatically enhanced the osteogenic differentiation of MC3T3-E1 cells as shown from the higher cell proliferation, alkaline phosphatase activity and bone-like nodule formation when compared to pristine HA.
| Item Type: | Article |
|---|---|
| Funders: | Hanoi University of Science and Technology (HUST) (T2018-TT-206), National Foundation for Science & Technology Development (NAFOSTED) (104.03-2020-36) |
| Uncontrolled Keywords: | Magnesia; Sintering additive; Mechanical strength; Silicon-substituted hydroxyapatite; Cell responses |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Mar 2022 05:40 |
| Last Modified: | 29 Mar 2022 05:40 |
| URI: | http://eprints.um.edu.my/id/eprint/28329 |
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