Al Mamun, Mohammad and Wahab, Yasmin Abdul and Hossain, M. A. Motalib and Hashem, Abu and Johan, Mohd Rafie (2021) Electrochemical biosensors with aptamer recognition layer for the diagnosis of pathogenic bacteria: Barriers to commercialization and remediation. Trac-Trends in Analytical Chemistry, 145. ISSN 0165-9936, DOI https://doi.org/10.1016/j.trac.2021.116458.
Full text not available from this repository.Abstract
One of the serious public health threats is pathogenic bacteria due to the lack of affordable and early stage diagnosis and treatment. The existing diagnostic methods are tedious, time-consuming, expensive, and labor-intensive. Therefore, there is an urgent need for achieving simple, low-cost, precise, and rapid detection methods. Besides a plethora of efforts to meet those promises, electrochemical biosensors technologies with aptamers (synthetic ssDNA or ssRNA) recognition moieties have emerged as a promising sensing platform for bacterial diagnosis. In this review, we have comprehensively discussed the recent advances of different potentiometric and non-potentiometric electrochemical aptasensors emphasizing their surface designs, functionalization, and significant performance for the detection of pathogenic bacteria. At the end of this review, various quality advancements of aptasensors technologies, prospects, challenges, and boundaries of commercialization with research directions have been focused on and summarized. (c) 2021 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [ST030-2019], Universiti Malaya [RU001-2020] |
| Uncontrolled Keywords: | Aptamers; Nanomaterials; Functionalization; Potentiometric; Non-potentiometric; Aptasensors; Pathogenic bacteria; Commercialization |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 08 Apr 2022 04:01 |
| Last Modified: | 12 Apr 2022 06:54 |
| URI: | http://eprints.um.edu.my/id/eprint/27863 |
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