Rahman, Mohammad Tariqur and Idid, Syed Zahir (2021) Can Zn Be a Critical Element in COVID-19 Treatment? Biological Trace Element Research, 199 (2). pp. 550-558. ISSN 0163-4984, DOI https://doi.org/10.1007/s12011-020-02194-9.
Full text not available from this repository.Abstract
The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. Furthermore, Zn has the ability to enhance innate and adaptive immunity in the course of a viral infection. Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the infected cell can stop SARS-CoV-2 replication. Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Anti-viral drugs; Chloroquine; SARS-CoV-2; RNA dependent RNA polymerase; Zinc transporter; Pneumocytes |
| Subjects: | R Medicine |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 10 Mar 2022 02:52 |
| Last Modified: | 10 Mar 2022 02:52 |
| URI: | http://eprints.um.edu.my/id/eprint/27565 |
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