Wong, Siew Fang and Khor, Sook Mei (2021) Differential colorimetric nanobiosensor array as bioelectronic tongue for discrimination and quantitation of multiple foodborne carcinogens. Food Chemistry, 357. ISSN 0308-8146, DOI https://doi.org/10.1016/j.foodchem.2021.129801.
Full text not available from this repository.Abstract
Foodborne amides, specifically acrylamide, are vitally important for food safety and security, as they are the most common food toxicants and suspected human carcinogens. A facile and novel differential-based colorimetric nanobiosensor array composed of three surface-bioengineered gold nanoparticles (AuNPs) was developed for the rapid detection, differentiation, and quantification of acrylamide and six analogues. Diverse cross-reactive receptors demonstrated differential binding affinities toward target analytes, resulting in distinctive AuNP aggregation behaviors and distinguishable response patterns. The sensor array, integrated with principal component analysis and hierarchical cluster analysis, accurately discriminated foodborne amides based on their amine subgroups, International Agency for Research on Cancer (IARC) carcinogen classifications, and food additive types, even at ultra-low concentrations (500 pM). Additionally, the sensor array successfully differentiated nontargeted analytes by sweetener and food ingredients types with 100% correct classification. Partial least squares regression outcomes exhibited high correlation coefficients (R2 > 0.95). Thus, the sensor array has practical potential for food safety monitoring in the food and beverage industries.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education of Malaysia (MOHE)[FP035-2019A] |
| Uncontrolled Keywords: | Acrylamide; Differential sensing; Principal component analysis; Hierarchical cluster analysis; Nanoparticle-protein interactions |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 Apr 2022 02:29 |
| Last Modified: | 14 Apr 2022 02:29 |
| URI: | http://eprints.um.edu.my/id/eprint/26920 |
Actions (login required)
 |
View Item |
