Lwin, Ohn Mar and Giribabu, Nelli and Kilari, Eswar Kumar and Salleh, Naguib (2021) Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats. Journal of Dermatological Treatment, 32 (8). pp. 1039-1048. ISSN 0954-6634, DOI https://doi.org/10.1080/09546634.2020.1721419.
Full text not available from this repository.Abstract
Purpose: This study identifies the potential use of mangiferin gel to promote wound healing in diabetes mellitus (DM). Materials and methods: Male rats were rendered diabetes mellitus via intraperitoneal injection of streptozotocin and nicotinamide. Following diabetes development, wound was created at the back of the neck. 1% and 2% mangiferin gel and 1% silver sulphurdiazine (SS) gel (positive control) were applied to the wound for twenty-one (21) days. Fasting blood glucose (FBG) levels were weekly monitored. At the end of the treatment, rats were sacrificed and wound was excised and subjected for histopathological and molecular biological analysis. Results: No changes to serum FBG levels was noted throughout the period of mangiferin treatment. Albeit, a significant decrease in the size of the wound with increased in the skin thickness of surrounding the wound were observed. Increased expression and distribution of EGF, FGF, TGF-beta, VEGF, PI3K, MMP and Nrf2 and decreased expression and distribution of TNF alpha and NF-kappa B p65 were observed in diabetic wound treated with topical mangiferin. Conclusions: Mangiferin has potential to be used as an agent to promote wound healing in diabetic condition.
| Item Type: | Article |
|---|---|
| Funders: | AICTE RPS project, India [A.V. (3)/AICTE-RPS/2014] |
| Uncontrolled Keywords: | Topical; Mangiferin; Wound healing; Diabetes mellitus |
| Subjects: | R Medicine > RL Dermatology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Apr 2022 07:15 |
| Last Modified: | 15 Apr 2022 07:15 |
| URI: | http://eprints.um.edu.my/id/eprint/26747 |
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