Loganadan, Navin Kumar and Huri, Hasniza Zaman and Vethakkan, Shireene Ratna and Hussein, Zanariah (2021) Pharmacogenetics of sulfonylurea-induced hypoglycemia in type 2 diabetes patients: The SUCLINGEN study. Pharmacogenomics, 22 (16). pp. 1057-1068. ISSN 1462-2416, DOI https://doi.org/10.2217/pgs-2021-0059.
Full text not available from this repository.Abstract
Aim: This study investigated the incidence of sulfonylurea-induced hypoglycemia and its predictors in Type 2 diabetes (T2D) patients. Patients & methods: In this prospective, observational study, T2D patients on maximal sulfonylurea-metformin therapy >1 year were enrolled. Hypoglycemia was defined as having symptoms or a blood glucose level Results: Of the 401 patients, 120 (29.9%) developed sulfonylurea-induced hypoglycemia during the 12-month follow-up. The ABCC8 rs757110, KCNJ11 rs5219, CDKAL1 rs7756992 and KCNQ1 rs2237892 gene polymorphisms were not associated with sulfonylurea-induced hypoglycemia (p > 0.05). Prior history of hypoglycemia admission (odds ratio = 16.44; 95% CI: 1.74-154.33, p = 0.014) independently predicted its risk. Conclusion: Sulfonylurea-treated T2D patients who experienced severe hypoglycemia are at increased risk of future hypoglycemia episodes.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (RP024-14HTM), Universiti Malaya (PG056-2014A) |
| Uncontrolled Keywords: | ABCC8 rs757110 polymorphism; CDKAL1 rs7756992 polymorphism; hypoglycemia; KCNJ11 rs5219 polymorphism; KCNQ1 rs2237892 polymorphism; Sulfonylurea |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Mar 2022 01:21 |
| Last Modified: | 18 Mar 2022 01:21 |
| URI: | http://eprints.um.edu.my/id/eprint/26561 |
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