Riazalhosseini, Behnaz and Mohamed, Rosmawati and Apalasamy, Yamunah Devi and Mohamed, Zahurin (2021) Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection. Pharmacogenetics and Genomics, 31 (9). pp. 185-190. ISSN 1744-6872, DOI https://doi.org/10.1097/FPC.0000000000000439.
Full text not available from this repository.Abstract
OBJECTIVE: The aim of this study is to examine the association between genetic variations in deleted in liver cancer 1 (DLC1) gene with progression of the hepatitis B virus (HBV) infection. METHODS: A total of 623 subjects were included in this study, of whom, 423 were chronic hepatitis B (CHB) patients without liver cirrhosis or hepatocellular carcinoma (HCC), 103 CHB with either liver cirrhosis ± HCC and 97 individuals who had resolved HBV. Two single-nucleotide polymorphisms rs3739298 and rs532841 of DLC1 gene were genotyped using the Sequenom MassARRAY platform. RESULTS: Our results indicated significant differences between the chronic HBV and resolved HBV groups in genotype and allele frequencies of DLC1-rs3739298 [odds ratio (OR) = 2.23; 95% confidence interval (CI): 1.24-3.99; P = 0.007] and (OR = 1.54; 95% CI: 1.07-2.22; P = 0.021), respectively. Moreover, haplotype analysis revealed significant associations between chronicity of HBV with TG and GA haplotypes (P = 0.041 and P = 0.042), respectively. CONCLUSION: A significant association exists between the rs3739298 variant and susceptibility to CHB infection. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | chronic hepatitis B; deleted in liver cancer 1 gene; hepatocellular carcinoma; liver cirrhosis; single-nucleotide polymorphism |
| Subjects: | R Medicine |
| Divisions: | Faculty of Economics & Administration Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Dec 2021 04:32 |
| Last Modified: | 29 Dec 2021 04:32 |
| URI: | http://eprints.um.edu.my/id/eprint/26095 |
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