Roux, Delphine and A. Hadi, A. Hamid and Thoret, Sylviane and Guénard, Daniel and Thoison, Odile and Païs, Mary and Sévenet, Thierry (2000) Structure−Activity Relationship of Polyisoprenyl Benzophenones fromGarcinia pyriferaon the Tubulin/Microtubule System. Journal of Natural Products, 63 (8). pp. 1070-1076. ISSN 0163-3864, DOI https://doi.org/10.1021/np0000872.
Full text not available from this repository.Abstract
Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure - activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Benzophenones; Butadienes; Chromatography, Gel; Chromatography, High Pressure Liquid; Fruit; Gas Chromatography-Mass Spectrometry; Hemiterpenes; Humans; KB Cells; Magnetic Resonance Spectroscopy; Malaysia; Microtubules; Optical Rotation; Pentanes; Plants, Medicinal; Rosales; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tubulin |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 02 Sep 2021 03:35 |
| Last Modified: | 02 Sep 2021 03:35 |
| URI: | http://eprints.um.edu.my/id/eprint/26018 |
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