Yong, Voon Wei and Tan, Yan Jing and Ng, Yi De and Choo, Xing Yan and Sugumaran, Kavita and Chinna, Karuthan and Md Shah, Mohammad Nazri and Raja Aman, Raja Rizal Azman and Moy, Foong Ming and Mohd Ramli, Norlisah and Grossmann, Mathis and Lim, Shen Yang and Tan, Ai Huey (2020) Progressive and accelerated weight and body fat loss in Parkinson's disease: A three-year prospective longitudinal study. Parkinsonism & Related Disorders, 77. pp. 28-35. ISSN 1353-8020, DOI https://doi.org/10.1016/j.parkreldis.2020.06.015.
Full text not available from this repository.Abstract
Introduction: Although weight loss is common in Parkinson's disease (PD), longitudinal studies assessing weight and body composition changes are limited. Methods: In this three-year longitudinal study, 125 subjects (77 PD patients and 48 spousal/sibling controls) underwent clinical, biochemical and body composition assessments using dual-energy X-ray absorptiometry. Results: Patients were older than controls (65.6 ± 8.9 vs. 62.6 ± 7.1, P = 0.049), with no significant differences in gender, comorbidities, dietary intake and physical activity. Clinically significant weight loss (≥5% from baseline weight) was recorded in 41.6% of patients, with a doubling of cases (6.5 to 13.0%) classified as underweight at study end. Over three years, patients demonstrated greater reductions in BMI (mean −1.2 kg/m2, 95%CI-2.0 to −0.4), whole-body fat percentage (−2.5% points, 95%CI-3.9 to −1.0), fat mass index (FMI) (−0.9 kg/m2, 95%CI-1.4 to −0.4), visceral fat mass (−0.1 kg, 95%CI-0.2 to 0.0), and subcutaneous fat mass (−1.9 kg, 95%CI-3.4 to −0.5) than in controls, with significant group-by-time interactions after adjusting for age and gender. Notably, 31.2% and 53.3% of patients had FMI<3rd (severe fat deficit) and <10th centiles, respectively. Muscle mass indices decreased over time in both groups, without significant group-by-time interactions. Multiple linear regression models showed that loss of body weight and fat mass in patients were associated with age, dyskinesia, psychosis and constipation. Conclusions: We found progressive loss of weight in PD patients, with greater loss of both visceral and subcutaneous fat, but not muscle, compared to controls. Several associated factors (motor and non-motor disease features) were identified for these changes, providing insights on possible mechanisms and therapeutic targets. © 2020
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Faculty Research Grant ( GPF018C-2018 ), University of Malaya Parkinson's Disease and Movement Disorder Research Program ( PV035-2017 ) |
| Uncontrolled Keywords: | Body composition; DXA; Fat; Nutrition; Parkinson's disease; Weight loss |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Feb 2021 01:19 |
| Last Modified: | 10 Feb 2021 01:19 |
| URI: | http://eprints.um.edu.my/id/eprint/25745 |
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