Obaid, Asma and Jamil, Arniza Khairani Mohd and Prabu, Samikannu and Saharin, Siti Munirah and Mohamad, Sharifah (2020) Spectroscopic studies for the inclusion complexation of ketoprofen enantiomers with β-cyclodextrin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 241. p. 118674. ISSN 1386-1425, DOI https://doi.org/10.1016/j.saa.2020.118674.
Full text not available from this repository.Abstract
Inclusion complexes of R-ketoprofen and S-ketoprofen enantiomers with β-cyclodextrin (β-CD) in aqueous solution were studied using various spectroscopic techniques such as Raman, FTIR, UV and fluorescence. The different relative intensities and characteristic band shifts of the two enantiomers from Raman spectra suggests different interaction when complexed with β-CD. Raman experiments revealed a noticeable diminishing of the C[dbnd]C vibration and ring deformation, which indicate the embedding of ketoprofen inside the β-CD cavity. It's revealed that distinct differences between R- and S-ketoprofen in the presence of β-CD at neutral pH. The stoichiometry ratio and binding constant of the inclusion complexes were calculated using Benesi–Hildebrand plot. Both enantiomers showed stoichiometry ratio of 1:1 inclusion complex with β-CD. The binding constant of R-ketoprofen (4088 M−1) is higher than S-ketoprofen (2547 M−1). These values indicated that β-CD formed inclusion complexes more preferentially with R-ketoprofen than S-ketoprofen. Results demonstrated that β-CD can be used as a promising chiral selector for ketoprofen enantiomers. © 2020 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme, Ministry of Higher Education ( MOHE ), Malaysia ( FP033-2019A ) |
| Uncontrolled Keywords: | Inclusion complexes; Spectrophotometry; β-Cyclodextrin; Ketoprofen enantiomers; Chiral recognition |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Sep 2020 01:31 |
| Last Modified: | 07 Sep 2020 01:31 |
| URI: | http://eprints.um.edu.my/id/eprint/25506 |
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