Omar, Hanita and Fadaeinasab, Mehran and Taha, Hairin and Widyawaruyanti, Aty and Nafiah, Mohd Azlan and Rachmatiah, Tiah (2020) Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana. Journal of Asian Natural Products Research, 22 (1). pp. 52-60. ISSN 1028-6020, DOI https://doi.org/10.1080/10286020.2018.1553958.
Full text not available from this repository.Abstract
One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Funders: | PPP Grant (PV091/ 2011B) and BKP Grant (BKP069-2016) from University of Malaya |
| Uncontrolled Keywords: | Phoebe tavoyana; Lauraceae; aporphine alkaloid; morphinandienone; antiplasmodial; Plasmodium falciparum |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Centre for Foundation Studies in Science > Chemistry Division Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Aug 2020 08:40 |
| Last Modified: | 25 Aug 2020 08:40 |
| URI: | http://eprints.um.edu.my/id/eprint/25457 |
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