Rahman, Mohammad Azizur and Hossain, Shahdat and Abdullah, Noorlidah and Aminudin, Norhaniza (2020) Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease. International Journal of Medicinal Mushrooms, 22 (1). pp. 93-103. ISSN 1521-9437, DOI https://doi.org/10.1615/IntJMedMushrooms.2020033383.
Full text not available from this repository.Abstract
Hypercholesterolemia has been implicated as one of the pathomechanistic factors of Alzheimer’s disease (AD), the most common neurodegenerative disorder affecting memory and learning abilities. In the present study, ameliorative effect of hot water extract (HWE) of mushroom Ganoderma lucidum to the memory and learning related behavioral performance of hypercholesterolemic and AD rats was investigated using Morris water maze (MWM). Male Wistar rats were randomly grouped into control, extract fed control, hypercholesterolemic, extract fed hypercholesterolemic, AD, and extract fed AD groups, each group containing 8 animals. Hypercholesterolemia was induced in rats by adding 1% cholesterol and 1% cholic acid with the basal diet of the respective group. Alzheimer’s disease model rats were prepared through infusion of amyloid β(1-42) to the right ventricle. Memory and learning related performance of all the rats was tested for 6 consecutive days that included time taken to reach the submerged platform (sec) and distance traveled (m). G. lucidum HWE fed rats took less time and traveled less distance to find the submerged platform, which indicates the spatial learning and memory related behavioral amelioration of the extract fed rats compared with their nonfed counterparts. Thus, usage of G. lucidum seems promising in withstanding hypercholesterolemia-induced Alzheimer’s disease pathogenesis. © 2020 by Begell House, Inc.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya and the Ministry of Higher Education, Malaysia for the HIR-MOHE Research Grant F000002-21001 funding |
| Uncontrolled Keywords: | Ganoderma lucidum; Alzheimer's disease; amyloid beta; hypercholesterolemia; oxidative stress; Morris water maze; medicinal mushrooms |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Aug 2020 03:43 |
| Last Modified: | 14 Aug 2020 03:43 |
| URI: | http://eprints.um.edu.my/id/eprint/25355 |
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