Ramdas, Premdass and Radhakrishnan, Ammu Kutty and Abdu Sani, Asmahani Azira and Kumari, Mangala and Anandha Rao, Jeya Seela and Abdul-Rahman, Puteri Shafinaz (2019) Advancing the Role of Gamma-Tocotrienol as Proteasomes Inhibitor: A Quantitative Proteomic Analysis of MDA-MB-231 Human Breast Cancer Cells. Biomolecules, 10 (1). p. 19. ISSN 2218-273X, DOI https://doi.org/10.3390/biom10010019.
Full text not available from this repository.Abstract
Tocotrienol, an analogue of vitamin E has been known for its numerous health benefits and anti-cancer effects. Of the four isoforms of tocotrienols, gamma-tocotrienol (γT3) has been frequently reported for their superior anti-tumorigenic activity in both in vitro and in vivo studies, when compared to its counterparts. In this study, the effect of γT3 treatment in the cytoplasmic and nuclear fraction of MDA-MB-231 human breast cancer cells were assessed using the label-free quantitative proteomics analysis. The cytoplasmic proteome results revealed the ability of γT3 to inhibit a group of proteasome proteins such as PSMA, PSMB, PSMD, and PSME. The inhibition of proteasome proteins is known to induce apoptosis in cancer cells. As such, the findings from this study suggest γT3 as a potential proteasome inhibitor that can overcome deficiencies in growth-inhibitory or pro-apoptotic molecules in breast cancer cells. The nuclear proteome results revealed the involvement of important nuclear protein complexes which hardwire the anti-tumorigenesis mechanism in breast cancer following γT3 treatment. In conclusion, this study uncovered the advancing roles of γT3 as potential proteasomes inhibitor that can be used for the treatment of breast cancer. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
|---|---|
| Funders: | Fundamental Research Grant Scheme (FRGS, FP016–2013B) from the Ministry of Higher Education, Malaysia, Frontier Research Grant UM (FRG, FG018–17AFR), UM Research Grant (RG082/09AFR) from University Malaya, Malaysia |
| Uncontrolled Keywords: | vitamin E; tocotrienols; mass spectrometry; proteasomes; breast cancer |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Aug 2020 08:23 |
| Last Modified: | 13 Aug 2020 08:23 |
| URI: | http://eprints.um.edu.my/id/eprint/25339 |
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