Ramli, Norlisah and Yap, A. and Muridan, Roziah and Seow, Poh Choo and Rahmat, Kartini and Fong, Choong Yi and Tan, Li Kuo and Ong, Lai Choo (2020) Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study. Clinical Radiology, 75 (1). 77.e15-77.e22. ISSN 0009-9260, DOI https://doi.org/10.1016/j.crad.2019.09.134.
Full text not available from this repository.Abstract
AIM: To evaluate the microstructural abnormalities of the white matter tracts (WMT) using diffusion tensor imaging (DTI) in children with global developmental delay (GDD). MATERIALS AND METHODS: Sixteen children with GDD underwent magnetic resonance imaging (MRI) and cross-sectional DTI. Formal developmental assessment of all GDD patients was performed using the Mullen Scales of Early Learning. An automated processing pipeline for the WMT assessment was implemented. The DTI-derived metrics of the children with GDD were compared to healthy children with normal development (ND). RESULTS: Only two out of the 17 WMT demonstrated significant differences (p<0.05) in DTI parameters between the GDD and ND group. In the uncinate fasciculus (UF), the GDD group had lower mean values for fractional anisotropy (FA; 0.40 versus 0.44), higher values for mean diffusivity (0.96 versus 0.91×10−3 mm2/s) and radial diffusivity (0.75 versus 0.68×10−3 mm2/s) compared to the ND group. In the superior cerebellar peduncle (SCP), mean FA values were lower for the GDD group (0.38 versus 0.40). Normal myelination pattern of DTI parameters was deviated against age for GDD group for UF and SCP. CONCLUSION: The UF and SCP WMT showed microstructural changes suggestive of compromised white matter maturation in children with GDD. The DTI metrics have potential as imaging markers for inadequate white matter maturation in GDD children. © 2019 The Royal College of Radiologists
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant ( UMRG: RP052B-17HTM ) |
| Uncontrolled Keywords: | Diffusion Weighted Imaging; White Matter; High Angular Resolution |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Aug 2020 08:13 |
| Last Modified: | 13 Aug 2020 08:13 |
| URI: | http://eprints.um.edu.my/id/eprint/25337 |
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