Sakharkar, Meena Kishore and Dhillon, Sarinder Kaur and Chidambaram, Saravana Babu and Essa, Musthafa Mohamed and Yang, Jian (2020) Gene Pair Correlation Coefficients in Sphingolipid Metabolic Pathway as a Potential Prognostic Biomarker for Breast Cancer. Cancers, 12 (7). p. 1747. ISSN 2072-6694, DOI https://doi.org/10.3390/cancers12071747.
Full text not available from this repository.Abstract
Complex diseases such as cancer are usually governed by dynamic and simultaneous modifications of multiple genes. Since sphingolipids are potent bioactive molecules and regulate many important pathophysiological processes such as carcinogenesis, we studied the gene pair correlations of 36 genes (31 genes in the sphingolipid metabolic pathway and 5 genes encoding the sphingosine-1-phosphate receptors) between breast cancer patients and healthy controls. It is remarkable to observe that the gene expressions were widely and strongly correlated in healthy controls but in general lost in breast cancer patients. This study suggests that gene pair correlation coefficients could be applied as a systematic and novel method for the diagnosis and prognosis of breast cancer. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Biomarker; Breast cancer; Gene expression; Gene pair correlation; Sphingolipid |
| Subjects: | Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Jul 2020 01:44 |
| Last Modified: | 28 Jul 2020 01:44 |
| URI: | http://eprints.um.edu.my/id/eprint/25191 |
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