Lee, Hui Min and Sia, Alice Pei Eal and Li, Lili and Sathasivam, Hans Prakash and Chan, Melissa Sue Ann and Rajadurai, Pathmanathan and Tsang, Chi Man and Tsao, Sai Wah and Murray, Paul G. and Tao, Qian and Paterson, Ian Charles and Yap, Lee Fah (2020) Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma. Scientific Reports, 10. p. 6115. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-020-63150-0.
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Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma.pdf Download (5MB) | Preview |
Abstract
Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines. Depending on the cancer type, MAOA can either have a tumour-promoting or tumour-suppressive role. We show that MAOA is down-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells. In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and malignant nasopharyngeal epithelial (NPE) cells. We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might be attributed to EBV infection in NPE cells. Taken together, our data point to a central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could be an important step in the pathogenesis of NPC.
| Item Type: | Article |
|---|---|
| Funders: | Newton-Ungku Omar Fund MR/P013201 (IF016-2017) from the Academy of Sciences Malaysia and Medical Research Council UK, Fundamental Research Grant Scheme (FP013-2016) from the Ministry of Higher Education Malaysia |
| Uncontrolled Keywords: | epstein-barr-virus; stat3 activation; a expression; metastasis; gene; contributes; system; grade; mao; Science & Technology - Other Topics |
| Subjects: | R Medicine > RK Dentistry > Practice of dentistry. Dental economics |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 13 Jul 2020 02:19 |
| Last Modified: | 13 Jul 2020 02:19 |
| URI: | http://eprints.um.edu.my/id/eprint/25008 |
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