Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus

Kuppusamy, U.R. and Indran, M. and Ahmad, T.S. and Wong, S.W. and Tan, S.Y. and Mahmood, A.A. (2005) Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus. Clinica Chimica Acta, 351 (1-2). pp. 197-201. ISSN 0009-8981,

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Abstract

Background: Comparisons of oxidative indices and total antioxidant status between end-stage renal disease (ESRD) patients with or without diabetes is scant, especially in the Asian population. Method: The assays were carried out according to known established protocols. Result: The present study showed that ESRD patients with or without non-insulin-dependent diabetes mellitus (NIDDM) did not have any significant differences in antioxidant enzyme activities, advanced glycated end products (AGE), advanced oxidized protein products (AOPP) and ferric reducing ability of plasma (FRAP), indicating that hyperglycemia does not exacerbate oxidative damage in ESRD. The regulation of catalase and glutathione peroxidase is also altered in ESRD. Elevated FRAP was observed in both ESRD groups (with and without NIDDM). The dialysis process did not alter the antioxidant enzyme activities but decreased AGEs and FRAP and increased AOPP levels. Conclusion: Oxidative stress is present in ESRD but this is not significantly exacerbated by hyperglycemia. The contribution of components in the pathology of renal failure towards oxidative stress exceeds that of hyperglycemia. D 2004 Elsevier B.V. All rights reserved.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Corresponding author. Tel.: +603 79674900; fax: +603 79676600. E-mail address: umah@um.edu.my (U.R. Kuppusamy).
Uncontrolled Keywords:	ESRD with/without NIDDM; oxidative stress
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Nor Izzati Ab Razak
Date Deposited:	25 Jan 2012 02:01
Last Modified:	20 Oct 2014 05:18
URI:	http://eprints.um.edu.my/id/eprint/2488

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