Yii, Raymond Shi Liang and Lim, Jasmine and Sothilingam, Selvalingam and Yeoh, Wei Sien and Fadzli, Ahmad Nazran and Ong, Teng Aik and Kuppusamy, Shanggar and Razack, Azad Hassan Abdul (2020) Predictive factors of prostate cancer diagnosis with PSA 4.0–10.0 ng/ml in a multi-ethnic Asian population, Malaysia. Asian Journal of Surgery, 43 (1). pp. 87-94. ISSN 1015-9584, DOI https://doi.org/10.1016/j.asjsur.2019.02.014.
Full text not available from this repository.Abstract
Objectives: To identify the associated factors determining prostate cancer detection using transrectal ultrasound (TRUS)-guided prostate biopsy, within a multi-ethnic Malaysian population with prostate specific antigen (PSA) between 4.0 and 10.0 ng/ml. Methods: Study subjects included men with initial PSA between 4.0 and 10.0 ng/ml that have undergone 12-core TRUS-guided prostate biopsy between 2009 and 2016. The prostate cancer detection rate was calculated, while potential factors associated with detection were investigated via univariable and multivariable analysis. Results: A total of 617 men from a multi-ethnic background encompassing Chinese (63.5%), Malay (23.1%) and Indian (13.3%) were studied. The overall cancer detection rate was 14.3% (88/617), which included cancers detected at biopsy 1 (first biopsy), biopsy 2 (second biopsy with previous negative biopsy) and biopsy ≥ 3 (third or more biopsies with prior negative biopsies). Indian men displayed higher detection rate (23.2%) and increased risk of prostate cancer development (OR 1.85, 95% CI 1.03–3.32, p < 0.05), compared to their Malay (9.8%) and Chinese (14.0%) counterparts. Multivariable analysis revealed that ethnicity and PSA density (PSAD) are independent factors associated with overall prostate cancer detection rate. A unit increase of PSAD reflected an increase in PSA after controlling for prostate volume. Conclusion: Prostate cancer detection in Malaysia is comparatively lower. Our study suggests that ethnicity and PSA density should be considered when recommending first or repeat TRUS-guided prostate biopsy for prostate cancer detection in a multi-ethnic Malaysian population. © 2019
| Item Type: | Article |
|---|---|
| Funders: | University Malaya High Impact Research Grant (HIR/MOHE/MED/35) |
| Uncontrolled Keywords: | Prostate cancer; Prostate specific antigen (PSA); Prostate volume; Transrectal ultrasound (TRUS)-Guided biopsy |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 04 Jun 2020 03:39 |
| Last Modified: | 04 Jun 2020 03:39 |
| URI: | http://eprints.um.edu.my/id/eprint/24651 |
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