Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta

Ajay, M. and Gilani, A.H. and Mustafa, Mohd Rais (2003) Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sciences, 74 (5). pp. 603-612. ISSN 0024-3205,

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Abstract

The potency, structure-activity relationship, and mechanism of vasorelaxation of a series of flavonoids, representing different subclasses (flavonols: fisetin, rutin, quercetin; flavones: chrysin, flavone, baicalein; flavanones: naringenin, naringin; isoflavones: diadzein and flavanes: epigallo catechin gallate), were examined in the isolated rat aorta. Most of the flavonoids tested showed concentration dependent relaxant effects against K +(80 mM) and phenylephrine (PE, 0.1 AM)-induced contractions with a greater inhibition of the responses to the a1-adrenoceptor agonist. The relaxant effects of most of the flavonoids involve in part the release of nitric oxide and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses. In addition, the relaxant action of the flavonoids includes inhibition of Ca + 2 influx and release of Ca + 2 from intracellular stores. A structure-activity relationship amongst the flavonoids was suggested.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords:	Rat aorta; Flavonoids; Vasorelaxant; Structure-activity relationship
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	18 Jan 2012 02:20
Last Modified:	18 Dec 2019 06:11
URI:	http://eprints.um.edu.my/id/eprint/2463

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