Kalantari, Katayoon and Afifi, Amalina Muhammad and Moniri, Mona and Moghaddam, Amin Boroumand and Kalantari, Alireza and Izadiyan, Zahra (2019) Autoclave-assisted synthesis of AgNPs in Z. officinale extract and assessment of their cytotoxicity, antibacterial and antioxidant activities. IET Nanobiotechnology, 13 (3). pp. 262-268. ISSN 1751-8741, DOI https://doi.org/10.1049/iet-nbt.2018.5066.
Full text not available from this repository.Abstract
In this study, the authors synthesised silver nanoparticles (AgNPs) using autoclave as a simple, unique and eco-friendly approach. The effect of Zingiber officinale extract was evaluated as a reducing and stabiliser agent. According to transmission electron microscopy results, the AgNPs were in the spherical shape with a particle size of ∼17 nm. The biomedical properties of AgNPs as antibacterial agents and free radical scavenging activity were estimated. Synthesised AgNPs showed significant 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging. Strong bactericidal activity was shown by the AgNPs on Gram-positive and Gram-negative bacteria. A maximum inhibition zone of ∼14 mm was obtained for epidermidis at a concentration of 60 μg/ml for sample fabricated at 24 h. The AgNPs also showed a significant cytotoxic effect against MCF-7 breast cancer cell lines with an half maximal inhibitory concentration value of 62 μg/ml in 24 h by the MTT assay. It could be concluded that Z. officinale extract can be used effectively in the production of potential antioxidant and antimicrobial AgNPs for commercial application. © The Institution of Engineering and Technology 2018.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya (Research Grant no. RP034A-15AET), Ministry of Higher Education (MOHE FP026–2014B) |
| Uncontrolled Keywords: | Nanoparticles; Silver; Synthesized nanoparticles |
| Subjects: | T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 06 Apr 2020 15:40 |
| Last Modified: | 06 Apr 2020 15:40 |
| URI: | http://eprints.um.edu.my/id/eprint/24156 |
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