Ismail, Nur Amajeida and Salman, Abbas Abdulameer and Mohd Yusof, Mohd Sukeri and Che Soh, Siti Kamilah and Kadir Pahirulzaman, Khomaizon Abdul and Ali, Hapipah Mohd and Sarip, Rozie (2019) Synthesis, cytotoxicity and antineoplastic activities of novel acridine-based platinum(II) organometallic complexes. Journal of Organometallic Chemistry, 897. pp. 42-49. ISSN 0022-328X, DOI https://doi.org/10.1016/j.jorganchem.2019.06.024.
Full text not available from this repository.Abstract
Two new platinum(II) complexes incorporating acridine ligands with aniline moieties were successfully synthesised and characterised. The acridine-based ligands were synthesised by means of Ullmann's condensation. The reaction of cis-[PtCl2(DMSO)2] with the aforementioned ligand in a specified mol ratio gives 9-phenylaminoacridine cis-dichloro(dimethylsulfoxide)-platinum(II), 2a, and bis-[N-(3,5-dimethoxyphenyl) acridin-9-amine)]chloro platinum(II), 2b. Apparently, both complexes were slightly planar and in discrete asymmetrical units. Cytotoxicity and antineoplastic activity evaluations were conducted using WRL-68, MCF-7, HT-29, and HL60 cell lines. The novel complexes exhibited potent activity towards the cell lines. Concurrently, the MTT cytotoxicity assay revealed that all complexes significantly inhibited the proliferation of MCF-7 and HL60 cells. © 2019 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya IPPP Grant [ PG107-2016A ], University of Malaya Research Grant (UMRG)-AFR (Frontier Science) [ RG357-15AFR ], Fundamental Research Grant Scheme (FRGS) [ FP047-2014A ] |
| Uncontrolled Keywords: | Acridine; Anticancer; Platinum |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Mar 2020 04:09 |
| Last Modified: | 26 Mar 2020 04:09 |
| URI: | http://eprints.um.edu.my/id/eprint/24099 |
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