Niek, Wen Kiong and Teh, Cindy Shuan Ju and Idris, Nuryana and Thong, Kwai Lin and Ponnampalavanar, Sasheela (2019) Predominance of ST22-MRSA-IV clone and emergence of clones for methicillin-resistant staphylococcus aureus clinical isolates collected from a tertiary teaching hospital over a two-year period. Japanese Journal of Infectious Diseases, 72 (4). pp. 228-236. ISSN 1344-6304, DOI https://doi.org/10.7883/yoken.JJID.2018.289.
Full text not available from this repository.Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common nosocomial pathogens, causing mild to severe infections. This study aimed to determine the genotypic and phenotypic characteristics of clinical MRSA isolates collected from a teaching hospital from 2014 - 2015. These isolates were genotyped by multilocus sequence typing (MLST), staphylococcal cassette chromosomal mec (SCCmec) typing, virulence genes detection and pulsed-field gel electrophoresis (PFGE) and phenotyped based on their vancomycin susceptibility profiles. The most prevalent sequence type was ST22. ST3547 was identified from a blood isolate from 2015. Three SCCmec types (III in 26.26%, IV in 70.71% and V in 3.03%) were detected. Agr type I, II, III were detected among the isolates. The most prevalent virulence genes were hemolysin (100%) and intracellular adhesion (91.9%). At least one staphylococcal enterotoxins was detected in 83 (83.8%) of the isolates. All of the isolates were susceptible to vancomycin (MIC ≤ 2 µg/ml). Statistical analysis revealed significant increase in hypertension (p = 0.035), dyslipidemia and obesity (p = 0.046), and previous exposure to any quinolone (p = 0.010) cases over the two-year period. Emergence and circulation of community-associated MRSA variants were observed in our hospital. © 2019, National Institute of Health. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | FRGS, MOE (FP016-2014B), UM BKP Grant (BK075-2016) |
| Uncontrolled Keywords: | Methicillin-Resistant Staphylococcus aureus; Staphylococcus aureus; Chromosome mec |
| Subjects: | Q Science > QR Microbiology R Medicine |
| Divisions: | Faculty of Medicine Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Feb 2020 01:31 |
| Last Modified: | 19 Feb 2020 01:31 |
| URI: | http://eprints.um.edu.my/id/eprint/23832 |
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