Tan, Nur Amanina Syariff and Giribabu, Nelli and Karim, Kamarulzaman and Nyamathulla, Shaik and Salleh, Naguib (2019) Intravaginal treatment with Marantodes pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition. Journal of Ethnopharmacology, 236. pp. 9-20. ISSN 0378-8741, DOI https://doi.org/10.1016/j.jep.2019.02.027.
Full text not available from this repository.Abstract
Ethnopharmacological relevance: Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown. Aims: To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Methods: Ovariectomized female Sprague-Dawley rats received MP (100 μg/ml, 250 μg/ml and 500 μg/ml) and estriol (E) gels intravaginally for seven consecutive days. Rats were then euthanized and vagina was harvested and subjected for histological and protein expression and distribution analyses. Vaginal ultrastructure was observed by transmission electron microscopy (TEM). Results: Thickness of vaginal epithelium increased with increasing intravaginal MP doses. Additionally, increased in expression and distribution of proliferative protein i.e. PCNA, tight junction protein i.e. occludin, water channel proteins i.e. AQP-1 and AQP-2 and proton extruder protein i.e. V-ATPase A1 were observed in the vagina following intravaginal MP and E gels treatment. Intravaginal MP and E gels also induced desmosome formation and approximation of the intercellular spaces between the vaginal epithelium. Conclusions: Intravaginal MP was able to ameliorate features associated with VA; thus, it has potential to be used as an agent to treat this condition. © 2019 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Funders: | NKEA grant, Ministry of Agriculture and Agro-based Industries, Malaysia, grant number ( GA014-2014 ) |
| Uncontrolled Keywords: | Marantodes pumilum; Intravaginal gel; Sex-steroid deficient; VA |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Jan 2020 04:02 |
| Last Modified: | 03 Jan 2020 04:02 |
| URI: | http://eprints.um.edu.my/id/eprint/23296 |
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