Abidin, Mohamad Hamdi Zainal and Abdullah, Noorlidah and Abidin, Nurhayati Zainal (2018) Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro. International Journal of Medicinal Mushrooms, 20 (3). pp. 283-290. ISSN 1521-9437, DOI https://doi.org/10.1615/IntJMedMushrooms.2018025821.
Full text not available from this repository.Abstract
This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioavailability, as well as inhibition of endocan expression, was evaluated using human aortic endothelial cells (HAECs). Crude cold aqueous extract exhibited the most potent inhibitory activities against ACE and HMG-CoA reductase, with 61.79% and 44.30% inhibition, respectively. It also protected the bioavailability of NO released by HAECs, with 84.88% cell viability. The crude hot water extract was the most potent in inhibiting endocan expression, with 18.61% inhibition.
| Item Type: | Article |
|---|---|
| Funders: | Mushroom Research Centre, University of Malaya; the Ministry of Education, Malaysia: High Impact Research grant (Grant No. UM.C/625/1/HIR/MoE) |
| Uncontrolled Keywords: | ACE; HMG-CoA reductase; medicinal mushrooms; nitric oxide; Pleurotus pulmonarius |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Oct 2019 03:21 |
| Last Modified: | 14 Oct 2019 03:21 |
| URI: | http://eprints.um.edu.my/id/eprint/22730 |
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