Lee, Soo Ching and Chua, Ling Ling and Yap, Siew Hwei and Khang, Tsung Fei and Leng, Chan Yoon and Raja Azwa, Raja Iskandar and Lewin, Sharon R. and Kamarulzaman, Adeeba and Woo, Yin Ling and Lim, Yvonne Ai Lian and Loke, P'ng and Rajasuriar, Reena (2018) Enrichment of gut-derived Fusobacterium is associated with suboptimal immune recovery in HIV-infected individuals. Scientific Reports, 8 (1). p. 14277. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-018-32585-x.
Full text not available from this repository.Abstract
We explored the gut microbiota profile among HIV-infected individuals with diverse immune recovery profiles following long-term suppressive ART and investigated the relationship between the altered bacteria with markers of immune dysfunction. The microbiota profile of rectal swabs from 26 HIV-infected individuals and 20 HIV-uninfected controls were examined. Patients were classified as suboptimal responders, sIR (n = 10, CD4 T-cell <350 cells/ul) and optimal responders, oIR (n = 16, CD4 T-cell >500 cells/ul) after a minimum of 2 years on suppressive ART. Canonical correlation analysis(CCA) and multiple regression modelling were used to explore the association between fecal bacterial taxa abundance and immunological profiles in optimal and suboptimal responders. We found Fusobacterium was significantly enriched among the HIV-infected and the sIR group. CCA results showed that Fusobacterium abundance was negatively correlated with CD4 T-cell counts, but positively correlated with CD4 T-cell activation and CD4 Tregs. Multiple linear regression analysis adjusted for age, baseline CD4 T-cell count, antibiotic exposure and MSM status indicated that higher Fusobacterium relative abundance was independently associated with poorer CD4 T-cell recovery following ART. Enrichment of Fusobacterium was associated with reduced immune recovery and persistent immune dysfunction following ART. Modulating the abundance of this bacterial taxa in the gut may be a viable intervention to improve immune reconstitution in our setting.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Fusobacterium; suboptimal immune recovery; HIV-infected individuals |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine Faculty of Science > Institute of Mathematical Sciences Centre of Excellence for Research in AIDS (CERiA) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Jun 2019 09:08 |
| Last Modified: | 17 Jun 2019 09:08 |
| URI: | http://eprints.um.edu.my/id/eprint/21499 |
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