Sarraf, Masoud and Dabbagh, Ali and Bushroa, Abdul Razak and Nasiri-Tabrizi, Bahman and Hosseini, Hamid Reza Madaah and Saber-Samandari, Saeed and Abu Kasim, Noor Hayaty and Lum, Kah Yean and Sukiman, Nazatul Liana (2018) Silver oxide nanoparticles-decorated tantala nanotubes for enhanced antibacterial activity and osseointegration of Ti6Al4V. Materials & Design, 154. pp. 28-40. ISSN 0261-3069, DOI https://doi.org/10.1016/j.matdes.2018.05.025.
Full text not available from this repository.Abstract
A long-term antibacterial activity of implants without compromising their biocompatibility is highly desirable to minimize the biomaterial-associated infections. Although tantalum oxide nanotubes (Ta2O5 NTs) are promising coating materials for orthodontics and orthopedics applications, their insufficient antibacterial activity retains vulnerability to post-implantation infections. This study aimed to endow antibacterial characteristics to the Ta2O5 NTs-coated Ti6Al4V substrates by decoration of silver oxide nanoparticles (Ag2O NPs). The well-adherent Ta2O5 NTs were grown via anodization of a pure tantalum (Ta) layer coated by physical vapor deposition (PVD) on the Ti6Al4V substrates. The Ag2O NPs were then decorated on the edges and walls of nanotubes through a secondary PVD under controlled conditions. The silver oxide nanoparticles-decorated tantala nanotubes (Ag2O NPs-decorated Ta2O5 NTs) promoted the formation of bone-like apatite layer and significantly reduced the viability of Escherichia coli (E. coli) cells. The prepared coating also increased the density and spreading of osteoblast cells in comparison to bare substrate. These results suggest that decorating the Ta2O5 NTs with Ag2O nanoparticles could improve antibacterial activity and the osseointegration of Ti6Al4V implants.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Research Grant (RP032C-15AET), University of Malaya Postgraduate Research Grant (PG081-2014B), Fundamental Research Grant Scheme (FRGS/1/2015/TK05/UM/02/8) |
| Uncontrolled Keywords: | Ta2O5 nanotubes; Ag2O nanoparticles; Antibacterial activity; Apatite layer; Human osteoblasts |
| Subjects: | R Medicine R Medicine > RK Dentistry T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Faculty of Dentistry Faculty of Engineering Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Mar 2019 03:09 |
| Last Modified: | 05 Dec 2019 05:48 |
| URI: | http://eprints.um.edu.my/id/eprint/20766 |
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