Vikneswaran, R. and Syafiq, M.S. and Eltayeb, N.E. and Kamaruddin, M.N. and Ramesh, Subramaniam and Yahya, Rosiyah (2015) A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 150. pp. 175-180. ISSN 1386-1425, DOI https://doi.org/10.1016/j.saa.2015.05.087.
Full text not available from this repository.Abstract
Copper ion recognition and DNA interaction of a newly synthesized fluorescent Schiff base (HPyETSC) were investigated using UV-vis and fluorescent spectroscopy. Examination using these two techniques revealed that the detection of copper by HPyETSC is highly sensitive and selective, with a detection limit of 0.39 μm and the mode of interaction between HPyETSC and DNA is electrostatic, with a binding constant of 8.97 × 104 M-1. Furthermore, gel electrophoresis studies showed that HPyETSC exhibited nuclease activity through oxidative pathway.
| Item Type: | Article |
|---|---|
| Funders: | University Malaya: University of Malaya Research Grant (RP025A-14AFR), High Impact Research Grant (J-21002-73851) and Postgraduate Research Grant (PG105-2012B), University Malaya: Bright Sparks fellowship (BSP/APP/0944/2013) |
| Uncontrolled Keywords: | Thiosemicarbazone; Fluorescent; Chemosensor; DNA binding; Chemical nucleases |
| Subjects: | Q Science > Q Science (General) Q Science > QC Physics Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry Faculty of Science > Department of Physics |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Oct 2018 03:19 |
| Last Modified: | 18 Mar 2019 08:30 |
| URI: | http://eprints.um.edu.my/id/eprint/19492 |
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